Psychedelics in Neuropsychiatric Research: Insights from Christina Dalla

Christina Dalla, an esteemed professor of pharmacology, is pioneering research into the role of psychedelics in treating neuropsychiatric disorders. Her work has highlighted the importance of sex differences in drug responses, particularly concerning the effects of psychedelics like psilocybin and ketamine. Dalla's research indicates that hormonal fluctuations can influence how males and females respond to these substances, making it essential to consider these factors in clinical trials. She emphasizes that the psychedelic experience itself may be vital for therapeutic outcomes and that the presence of a therapist can enhance safety and efficacy. Dalla's ongoing studies aim to address whether the timing of psychedelic administration, particularly in relation to hormonal cycles, could optimize treatment benefits, particularly for women. As part of a broader European network, she is collaborating on preclinical studies to explore these dynamics, with a focus on understanding the mechanisms that drive sex-specific responses to psychedelics. This research could pave the way for innovative treatments in mental health care.